12/26/2023 0 Comments Trazodone for insomnia vs depression![]() ![]() ![]() © 2020 American Academy of Sleep Medicine. Registry: Name: Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia URL: Identifier: NCT01348542.Ĭognitive-behavioral therapy for insomnia cortisol insomnia insomnia short sleep duration phenotype total sleep time trazodone. The current preliminary, open-label, randomized trial suggests that trazodone, but not CBT-I, significantly improves objective sleep duration and reduces hypothalamic-pituitary-adrenal axis activation, suggesting a differential treatment response in the insomnia with objective short sleep duration phenotype. ![]() Finally, there were no differences on insomnia severity index scores between the trazodone and the CBT-I groups. In addition, trazodone, but not CBT-I, showed a clinically meaningful decrease in salivary cortisol from pretreatment to posttreatment (-36.07% vs -11.70% Cohen's d = 0.793) and from pretreatment to follow-up (-21.37% vs -5.79% Cohen's d = 0.284), respectively. Trazodone, but not CBT-I, significantly lengthened total sleep time (when measured with actigraphy) both at posttreatment (51.01 minutes vs -11.73 minutes P =. Mixed between-within-subjects analysis of variance and univariate analysis of covariance were conducted to assess the impact of trazodone and CBT-I on patients' total sleep time, salivary cortisol, and insomnia severity index scores across the 3 time points. Patients were examined with 2 weeks of actigraphy, salivary cortisol, and the insomnia severity index at 3 time points (pretreatment, 3-month posttreatment, and 6-month follow-up). You should avoid or limit the use of alcohol while being treated with traZODone. For example: Bupropion should not be used by people who have a seizure disorder or an eating disorder such as bulimia or anorexia. However, in some circumstances they can cause problems. Some people may also experience impairment in thinking and judgment. Atypical antidepressants are safe for most people. Eight patients were randomized to CBT-I and 7 to trazodone. Alcohol can increase the nervous system side effects of traZODone such as dizziness, drowsiness, and difficulty concentrating. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depression. If you take a monoamine oxidase inhibitor (MAOI). Trazodone hydrochloride tablets belong to a class of medicines known as SSRIs (or selective serotonin reuptake inhibitors). It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. Trazodone hydrochloride tablets are a prescription medicine used in adults to treat major depressive disorder (MDD). Participants included 15 patients with chronic insomnia (86.7% female), aged 45.3 ± 8.1 years. Trazodone is a medication used in the management and treatment of major depressive disorder. Whether insomnia with objective short sleep duration responds better to pharmacological treatment compared to CBT-I has not been examined. The insomnia with objective short sleep duration phenotype is associated with increased risk for adverse health outcomes, physiological hyperarousal, and a blunted response to cognitive behavioral therapy for insomnia (CBT-I). ![]()
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